Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer.

Fatemi, Nayeralsadat; Tu, Siang-Jyun; Chung, Chin-Chun; Moghadam, Pardis Ketabi; Mojarad, Ehsan Nazemalhosseini; Sadeghi, Amir; Totonchi, Mehdi; Aghdaei, Hamid Asadzadeh; Chang, Jan-Gowth

Fatemi, Nayeralsadat; Tu, Siang-Jyun; Chung, Chin-Chun; Moghadam, Pardis Ketabi; Mojarad, Ehsan Nazemalhosseini; Sadeghi, Amir; Totonchi, Mehdi; Aghdaei, Hamid Asadzadeh; Chang, Jan-Gowth.

Afiliação

Fatemi N; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tu SJ; Center for Precision Medicine, China Medical University Hospital, Taichung, Taiwan.
Chung CC; Center for Precision Medicine, China Medical University Hospital, Taichung, Taiwan.
Moghadam PK; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mojarad EN; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sadeghi A; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Totonchi M; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Aghdaei HA; Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Chang JG; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Kaohsiung J Med Sci ; 39(9): 896-903, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37314251

Assuntos

Neoplasias Colorretais; MAP Quinase Quinase Quinase 1; Humanos; Proteína 2 Homóloga a MutS/genética; Sequenciamento do Exoma; Mutação/genética; Neoplasias Colorretais/genética; Predisposição Genética para Doença; Proteína 1 Homóloga a MutL/genética; MAP Quinase Quinase Quinase 1/genética

Palavras-chave

colorectal cancer; early-onset; likely pathogenic; whole exome sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / MAP Quinase Quinase Quinase 1 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Kaohsiung J Med Sci Assunto da revista: MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã

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