Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING/NLRP3 signalling pathway.

Fang, Guangyao; Li, Xiuchuan; Yang, Fengyuan; Huang, Ting; Qiu, Chenming; Peng, Ke; Wang, Ziran; Yang, Yongjian; Lan, Cong

Fang, Guangyao; Li, Xiuchuan; Yang, Fengyuan; Huang, Ting; Qiu, Chenming; Peng, Ke; Wang, Ziran; Yang, Yongjian; Lan, Cong.

Afiliação

Fang G; College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, P.R. China.; Department of Cardiology, General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.
Li X; Department of Cardiology, General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.
Yang F; Department of Nephrology, General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.
Huang T; Department of Medical Oncology, People's Hospital of Luotian County, Huanggang, Hubei, P.R. China.
Qiu C; Department of Burn and Plastic Surgery, General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.
Peng K; Department of Cardiology, General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.
Wang Z; Department of Orthopedics, 903rd Hospital of PLA, Hangzhou, Zhejiang, P.R. China.
Yang Y; College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, P.R. China.; Department of Cardiology, General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.. Electronic address: yangyongjian38@sina.com.
Lan C; College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, P.R. China.; Department of Cardiology, General Hospital of Western Theater Command, Chengdu, Sichuan, P.R. China.. Electronic address: conglan100@yeah.net.

Phytomedicine ; 117: 154922, 2023 Aug.

Article em En | MEDLINE | ID: mdl-37321078

Assuntos

Neoplasias da Mama; Miócitos Cardíacos; Ratos; Camundongos; Animais; Humanos; Feminino; Piroptose; Cardiotoxicidade/tratamento farmacológico; Cardiotoxicidade/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Nigericina/efeitos adversos; Nigericina/metabolismo; Ratos Sprague-Dawley; Doxorrubicina/farmacologia; Proteínas Reguladoras de Apoptose/metabolismo; Inflamação/metabolismo; Neoplasias da Mama/patologia; Peso Corporal

Palavras-chave

Amentoflavone; Cardiomyocyte pyroptosis; Doxorubicin-induced cardiotoxicity; Inflammation; STING/NLRP3 signalling pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Miócitos Cardíacos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de publicação: Alemanha

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