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Wnt signaling preserves progenitor cell multipotency during adipose tissue development.
Yang Loureiro, Zinger; Joyce, Shannon; DeSouza, Tiffany; Solivan-Rivera, Javier; Desai, Anand; Skritakis, Pantos; Yang, Qin; Ziegler, Rachel; Zhong, Denise; Nguyen, Tammy T; MacDougald, Ormond A; Corvera, Silvia.
Afiliação
  • Yang Loureiro Z; Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Joyce S; Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • DeSouza T; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Solivan-Rivera J; Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Desai A; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Skritakis P; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Yang Q; Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Ziegler R; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Zhong D; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Nguyen TT; Division of Vascular Surgery, Department of Surgery, UMass Memorial Medical Center, Worcester, MA, USA.
  • MacDougald OA; Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Corvera S; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Nat Metab ; 5(6): 1014-1028, 2023 06.
Article em En | MEDLINE | ID: mdl-37337125
Mesenchymal stem/progenitor cells are essential for tissue development and repair throughout life, but how they are maintained under chronic differentiation pressure is not known. Using single-cell transcriptomics of human progenitor cells we find that adipose differentiation stimuli elicit two cellular trajectories: one toward mature adipocytes and another toward a pool of non-differentiated cells that maintain progenitor characteristics. These cells are induced by transient Wnt pathway activation and express numerous extracellular matrix genes and are therefore named structural Wnt-regulated adipose tissue cells. We find that the genetic signature of structural Wnt-regulated adipose tissue cells is present in adult human adipose tissue and adipose tissue developed from human progenitor cells in mice. Our results suggest a mechanism whereby adipose differentiation occurs concurrently with the maintenance of a mesenchymal progenitor cell pool, ensuring tissue development, repair and appropriate metabolic control over the lifetime.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Via de Sinalização Wnt Limite: Animals / Humans Idioma: En Revista: Nat Metab Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Via de Sinalização Wnt Limite: Animals / Humans Idioma: En Revista: Nat Metab Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Alemanha