Astaxanthin prevents osteoarthritis by blocking Rspo2-mediated Wnt/ß-catenin signaling in chondrocytes and abolishing Rspo2-related inflammatory factors in macrophages.

Zhu, Chunhui; Liu, Gang; Cui, Weiding; Yu, Zhongjie; Chen, Wei; Qin, Yao; Liu, Jiuxiang; Lu, Yaojun; Fan, Weimin; Liang, Wenwei

Zhu, Chunhui; Liu, Gang; Cui, Weiding; Yu, Zhongjie; Chen, Wei; Qin, Yao; Liu, Jiuxiang; Lu, Yaojun; Fan, Weimin; Liang, Wenwei.

Afiliação

Zhu C; Trauma Center, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, China.
Liu G; Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Cui W; Trauma Center, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, China.
Yu Z; Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Chen W; Trauma Center, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, China.
Qin Y; Trauma Center, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, China.
Liu J; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Lu Y; Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Fan W; Trauma Center, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, China.
Liang W; Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Aging (Albany NY) ; 15(12): 5775-5797, 2023 06 23.

Article em En | MEDLINE | ID: mdl-37354487

Assuntos

Condrócitos; Osteoartrite; Humanos; Condrócitos/metabolismo; beta Catenina/genética; beta Catenina/metabolismo; Osteoartrite/genética; Osteoartrite/prevenção & controle; Osteoartrite/metabolismo; Via de Sinalização Wnt; Macrófagos/metabolismo; Células Cultivadas

Palavras-chave

Rspo2; astaxanthin; chondrocytes; coculture; macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Condrócitos Limite: Humans Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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