Is the Golgi apparatus the obligatory final step for lipoprotein secretion by intestinal cells?
Tissue Cell
; 18(3): 447-60, 1986.
Article
em En
| MEDLINE
| ID: mdl-3738890
ABSTRACT
It is currently admitted that the synthesis and excretion of triglyceride-rich lipoproteins (chylomicrons and 'small chylomicrons') by intestinal epithelial cells involves the Golgi apparatus as an obligatory final step before exocytosis. The cells of the proximal intestine of the trout are an excellent model for investigating functional compartmentalization in the course of lipid absorption. Using this model, our data invalidate morphological data which were the basis for considering the Golgi apparatus as the mandatory final stage for their secretion. In particular, we show that triglyceride-rich particles can be transported directly from the endoplasmic reticulum to the intercellular space. Two pathways of intestinal lipoprotein excretion appear to coexist. One follows the classical export route, the second functions in a manner that bypasses the Golgi apparatus. The arguments used to affirm the requirement for the Golgi apparatus as a final step (glycosylation of apoprotein B, membrane vehicle for exocytosis) are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complexo de Golgi
/
Mucosa Intestinal
/
Lipoproteínas
Limite:
Animals
Idioma:
En
Revista:
Tissue Cell
Ano de publicação:
1986
Tipo de documento:
Article