Cryo-EM structures of actin binding proteins as tool for drug discovery.
Biochem Pharmacol
; 214: 115680, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37399949
ABSTRACT
Cellular actin dynamic is controlled by a plethora of actin binding proteins (ABPs), including actin nucleating, bundling, cross-linking, capping, and severing proteins. In this review, regulation of actin dynamics by ABPs will be introduced, and the role of the F-actin severing protein cofilin-1 and the F-actin bundling protein L-plastin in actin dynamics discussed in more detail. Since up-regulation of these proteins in different kinds of cancers is associated with malignant progression of cancer cells, we suggest the cryogenic electron microscopy (Cryo-EM) structure of F- actin with the respective ABP as template for in silico drug design to specifically disrupt the interaction of these ABPs with F-actin.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinas
/
Proteínas dos Microfilamentos
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha