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Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention.
Hagmann, Michelle; Baty, Florent; Rassouli, Frank; Maeder, Micha T; Brutsche, Martin H.
Afiliação
  • Hagmann M; Lung Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Baty F; Lung Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Rassouli F; Lung Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Maeder MT; Department of Cardiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Brutsche MH; Lung Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
PLoS One ; 18(7): e0288237, 2023.
Article em En | MEDLINE | ID: mdl-37418429
BACKGROUND: Nation-wide hospitalization databases include diagnostic information at the level of an entire population over an extended period of time. Comorbidity network and early disease development can be unveiled. Chronic obstructive pulmonary disease (COPD) is an underdiagnosed condition for which it is crucial to identify early disease indicators. The identification of gender-specific conditions preceding the onset of COPD may reveal disease progression patterns allowing for early diagnosis and intervention. The objective of the study was to investigate the antecedent hospitalization history of patients newly diagnosed with COPD and to retrace a gender-specific trajectory of coded entities prior to the onset of COPD. MATERIAL AND METHODS: A population-wide hospitalization database including information about all hospitalizations in Switzerland between 2002 and 2018 was used. COPD cases were extracted from the database and comorbidities occurring prior to the onset of COPD identified. Comorbidities significantly over-represented in COPD compared with a 1:1, age- and sex-matched control population were identified and their longitudinal evolution was analyzed. RESULTS: Between 2002 and 2018, 697,714 hospitalizations with coded COPD were recorded in Switzerland. Sixty-two diagnoses were significantly over-represented before onset of COPD. These preceding comorbidities included both well-established conditions and novel links to COPD. Early pre-conditions included nicotine and alcohol abuse, obesity and cardiovascular diseases. Later comorbidities included atrial fibrillation, diseases of the genitourinary system and pneumonia. Atherosclerotic heart diseases were more prevalent in males, whereas hypothyroidism, varicose and intestinal disorders were more frequent in females. Disease trajectories were validated using an independent data set. CONCLUSIONS: Gender-specific disease trajectories highlight early indicators and pathogenetic links between COPD and antecedent diseases and could allow for early detection and intervention.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos