Updates in histopathological classification and tissue biomarkers of digestive neuroendocrine neoplasms: What the clinician should know.
Best Pract Res Clin Endocrinol Metab
; 37(5): 101795, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37429760
ABSTRACT
Histopathological classifications of neuroendocrine neoplasms (NEN) change regularly and the latest WHO classification published in 2022, which concerns all NEN in the body, attempts to standardize classifications in the different locations. Differentiation and proliferation mainly assessed by Ki-67 index are still the cornerstone of those classifications. However, many markers are now used for diagnostic (to check neuroendocrine differentiation, to identify the site of origin of a metastasis, to help separating high-grade neuroendocrine tumors/NET and neuroendocrine carcinoma/NEC), prognostic or theranostic purposes. NENs are often heterogeneous and this can lead to difficulties in classifications, biomarker and prognostic assessment. These different points are discussed successively in this review, insisting especially on the frequent digestive, gastro-entero-pancreatic (GEP) localizations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Neoplasias Gástricas
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Tumores Neuroendócrinos
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Carcinoma Neuroendócrino
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Neoplasias Intestinais
Limite:
Humans
Idioma:
En
Revista:
Best Pract Res Clin Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2023
Tipo de documento:
Article