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Effects of Nutritional Interventions in Older Adults with Malnutrition or at Risk of Malnutrition on Muscle Strength and Mortality: Results of Pooled Analyses of Individual Participant Data from Nine RCTs.
van Zwienen-Pot, Judith I; Reinders, Ilse; de Groot, Lisette C P G M; Beck, Anne Marie; Feldblum, Ilana; Jobse, Inken; Neelemaat, Floor; de van der Schueren, Marian A E; Shahar, Danit R; Smeets, Ellen T H C; Tieland, Michael; Wijnhoven, Hanneke A H; Volkert, Dorothee; Visser, Marjolein.
Afiliação
  • van Zwienen-Pot JI; Research Centre Innovations in Care, Rotterdam University of Applied Sciences, 3015 EK Rotterdam, The Netherlands.
  • Reinders I; Department of Nutrition and Dietetics, Amsterdam University Medical Centers, Location VUmc, 1081 HV Amsterdam, The Netherlands.
  • de Groot LCPGM; Department of Health Sciences, Faculty of Science, Amsterdam Public Health Research Institute, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands.
  • Beck AM; Division of Human Nutrition and Health, Wageningen University & Research, 6703 HE Wageningen, The Netherlands.
  • Feldblum I; The Dietitians and Nutritional Research Unit, EATEN, Herlev and Gentofte Hospital, DK-2730 Herlev, Denmark.
  • Jobse I; The Daniel Abraham International Center for Health Nutrition, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba 84105, Israel.
  • Neelemaat F; Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, 90408 Nuremberg, Germany.
  • de van der Schueren MAE; Department of Nutrition and Dietetics, Amsterdam University Medical Centers, Location VUmc, 1081 HV Amsterdam, The Netherlands.
  • Shahar DR; Division of Human Nutrition and Health, Wageningen University & Research, 6703 HE Wageningen, The Netherlands.
  • Smeets ETHC; Department of Nutrition, Dietetics and Lifestyle, HAN University of Applied Sciences, 6525 EN Nijmegen, The Netherlands.
  • Tieland M; The Daniel Abraham International Center for Health Nutrition, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba 84105, Israel.
  • Wijnhoven HAH; Division of Human Nutrition and Health, Wageningen University & Research, 6703 HE Wageningen, The Netherlands.
  • Volkert D; Center of Expertise Urban Vitality, Amsterdam University of Applied Science, 1067 SM Amsterdam, The Netherlands.
  • Visser M; Department of Health Sciences, Faculty of Science, Amsterdam Public Health Research Institute, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands.
Nutrients ; 15(9)2023 Apr 22.
Article em En | MEDLINE | ID: mdl-37432139
Nutritional intervention studies in older adults with malnutrition aim to improve nutritional status. Although these studies show a significant gain in body weight, there is inconsistent evidence of clinical effectiveness on muscle strength and mortality. This study aimed to examine the effects of nutritional interventions on muscle strength and risk of mortality in older adults (malnourished or at risk) and explore whether these effects are influenced by participant characteristics. Individual participant data were used from nine RCTs (community setting, hospital and long-term care; duration 12-24 weeks and included oral nutritional supplements, dietary counseling, or both). Handgrip strength (HGS) was measured in seven RCTs and six RCTs obtained mortality data. A ≥3 kg increase in HGS was considered clinically relevant. Logistic generalized estimating equations analyses (GEE) were used to test intervention effectiveness. GEE showed no overall treatment effect (OR 1.11, 95% CI 0.78-1.59) on HGS. A greater, but not statistically significant, effect on HGS was observed for older (>80 years) versus younger participants. No significant treatment effect was observed for mortality (OR 0.78, 95% CI 0.42-1.46). The treatment effect on mortality was greater but remained non-significant for women and those with higher baseline energy or protein intake. In conclusion, no effects of nutritional interventions were observed on HGS and mortality in older adults (malnourished or at risk). While the treatment effect was modified by some baseline participant characteristics, the treatment also lacked an effect in most subgroups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Força da Mão / Desnutrição Tipo de estudo: Etiology_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Aged / Female / Humans Idioma: En Revista: Nutrients Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Força da Mão / Desnutrição Tipo de estudo: Etiology_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Aged / Female / Humans Idioma: En Revista: Nutrients Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda País de publicação: Suíça