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In vitro cytotoxicity of Mn(I) and Ru(II) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia.
Mansour, Ahmed M; Khaled, Rabaa M; Radacki, Krzysztof; Younes, Zeina; Gamal, Mariam; Guirguis, Beatrice; Mostafa, Gamal A E; Ali, Essam A; Shehab, Ola R.
Afiliação
  • Mansour AM; Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt. mansour@sci.cu.edu.eg.
  • Khaled RM; Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt. mansour@sci.cu.edu.eg.
  • Radacki K; Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany.
  • Younes Z; Department of Biotechnology, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
  • Gamal M; Department of Biotechnology, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
  • Guirguis B; Department of Biotechnology, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
  • Mostafa GAE; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Ali EA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Shehab OR; Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt. mansour@sci.cu.edu.eg.
Dalton Trans ; 52(30): 10286-10293, 2023 Aug 01.
Article em En | MEDLINE | ID: mdl-37466155
ABSTRACT
Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(I) and Ru(II) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(II) complex (IC50 = 7.13 ± 0.8 µM) displayed higher outstanding potency against leukaemia than the Mn(I) analogue (54.58 ± 4.1 µM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Leucemia Limite: Animals / Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Leucemia Limite: Animals / Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito