Evolving Approach to Clinical Cytometry for Immunodeficiencies and Other Immune Disorders.
Clin Lab Med
; 43(3): 467-483, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37481324
ABSTRACT
Primary immunodeficiencies were initially identified on the basis of recurrent, severe or unusual infections. Subsequently, it was noted that these diseases can also manifest with autoimmunity, autoinflammation, allergy, lymphoproliferation and malignancy, hence a conceptual change and their renaming as inborn errors of immunity. Ongoing advances in flow cytometry provide the opportunity to expand or modify the utility and scope of existing laboratory tests in this field to mirror this conceptual change. Here we have used the B cell subset, variably known as CD21low B cells, age-associated B cells and T-bet+ B cells, as an example to demonstrate this possibility.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos B
/
Síndromes de Imunodeficiência
/
Doenças do Sistema Imunitário
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Clin Lab Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos