Your browser doesn't support javascript.
loading
Assessment of selected muscle damage markers and zonulin concentration after maximum-intensity exercise in men with type 1 diabetes treated with a personal insulin pump.
Matejko, Bartlomiej; Tota, Lukasz; Morawska-Tota, Malgorzata; Palka, Tomasz; Malecki, Maciej T; Klupa, Tomasz.
Afiliação
  • Matejko B; Department of Metabolic Diseases, Jagiellonian University Medical College, ul. Jakubowskiego 2, 30-688, Krakow, Poland. b.matejko@uj.edu.pl.
  • Tota L; University Hospital in Krakow, Krakow, Poland. b.matejko@uj.edu.pl.
  • Morawska-Tota M; Department of Physiology and Biochemistry, University of Physical Education in Krakow, Krakow, Poland.
  • Palka T; Department of Sports Medicine and Human Nutrition, University of Physical Education in Krakow, Krakow, Poland.
  • Malecki MT; Department of Physiology and Biochemistry, University of Physical Education in Krakow, Krakow, Poland.
  • Klupa T; Department of Metabolic Diseases, Jagiellonian University Medical College, ul. Jakubowskiego 2, 30-688, Krakow, Poland.
Acta Diabetol ; 60(12): 1675-1683, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37481476
AIM: Exercise-induced muscle damage depends on exercise intensity and duration and on individual susceptibility. Mechanical and metabolic stress may disturb the intestinal microflora. The study evaluated selected muscle damage markers and zonulin concentration after maximum-intensity exercise in type 1 diabetes (T1D) men compared with healthy controls. METHODS: The study involved 16 T1D participants and 28 controls matched by age (22.7 [21.3-25.1] vs. 22.6 [20.9-26.3] years), body mass index (24.2 ± 1.6 vs. 24.2 ± 1.9 kg/m2), and body fat percentage (16.1 ± 5.2 vs. 14.9 ± 4.6%). The T1D group had 11.3 ± 5.1 years of diabetes duration and a suboptimal mean glycated haemoglobin level of 7.2 ± 1.1%. The subjects underwent a graded running treadmill test until exhaustion. Lactate concentration was assessed in arterialized blood at baseline and 3 and 20 min after the test. Cortisol, testosterone, tumour necrosis factor α, myoglobin, lactate dehydrogenase, zonulin, and vitamin D levels were evaluated in cubital fossa vein blood before and 60 min after the test. RESULTS: T1D patients presented higher baseline zonulin, myoglobin concentration, testosterone/cortisol ratio, and lower maximal oxygen uptake. On adjusting for the baseline values, the groups differed in zonulin, lactate dehydrogenase, and myoglobin levels, testosterone/cortisol ratio, and lactate concentration determined 20 min after exercise (P < 0.05). CONCLUSION: Maximum-intensity exercise increased muscle and intestinal damage in T1D participants. In patients with lower physical activity, very-high-intensity exercise should be recommended with caution. Observing the anabolic-catabolic index may help individualize effort intensity in T1D individuals.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 / Insulinas Limite: Humans / Male Idioma: En Revista: Acta Diabetol Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 / Insulinas Limite: Humans / Male Idioma: En Revista: Acta Diabetol Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia País de publicação: Alemanha