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Study of zeolite clinoptilolite d-glucose adsorption properties in vitro and in vivo.
Markoska, Rumenka; Stojkovic, Ranko; Filipovic, Marko; Jurin, Mladenka; Spada, Vedrana; Kavre Piltaver, Ivna; Pavelic, Kresimir; Markovic, Dean; Kraljevic Pavelic, Sandra.
Afiliação
  • Markoska R; University of Rijeka, Department of Biotechnology, Radmile Matejcic 2, 51000 Rijeka, Croatia.
  • Stojkovic R; Rudjer Boskovic Institute, Division of Molecular Medicine, Laboratory for Chiral Technologies, Bijenicka cesta 54, 10000 Zagreb, Croatia.
  • Filipovic M; Juraj Dobrila University of Pula, Zagrebacka 30, 52100 Pula, Croatia.
  • Jurin M; Rudjer Boskovic Institute, Division of Organic Chemistry and Biochemistry, Laboratory for Chiral Technologies, Bijenicka cesta 54, 10000 Zagreb, Croatia.
  • Spada V; Istarsko Veleuciliste - Università Istriana di scienze applicate, Riva 6, 52100 Pula, Croatia.
  • Kavre Piltaver I; University of Rijeka, Faculty of Physics and Centre for Micro- and Nanosciences and Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia.
  • Pavelic K; Juraj Dobrila University of Pula, Zagrebacka 30, 52100 Pula, Croatia.
  • Markovic D; University of Rijeka, Department of Biotechnology, Radmile Matejcic 2, 51000 Rijeka, Croatia.
  • Kraljevic Pavelic S; University of Rijeka, Faculty of Health Studies, Ulica Viktora Cara Emina 5, 51 000 Rijeka, Croatia. Electronic address: sandrakp@uniri.hr.
Chem Biol Interact ; 382: 110641, 2023 Sep 01.
Article em En | MEDLINE | ID: mdl-37482210
ABSTRACT
Beneficial effects of a natural zeolite clinoptilolite in vivo on mammals, including humans, have been empirically observed and documented in literature. The positive biological activities have been associated to its detoxifying and antioxidative properties, and its immunostimulative and adsorption properties. Herein, we present the in vitro and in vivo study of clinoptilolite zeolite materials adsorption properties for d-glucose. In particular, we present data on the interaction of d-glucose on the tested zeolites' surface obtained by scanning electron microscope (SEM) and Energy-dispersive X-ray spectroscopy (EDS) and quantification by ultra high-performance liquid chromatography (UHPLC). We also present results on the reduction of blood glucose levels in mice pre-treated with clinoptilolite in vivo upon feeding with d-glucose. In vivo results were in line with the in vitro adsorption and/or interaction properties of tested zeolite materials for d-glucose and were quantified by UHPLC as well (11.34% for TMAZ; 10.82% for PMA and 8.76% for PMAO2). In vivo experiments in mice showed that PMA zeolite reduces blood glucose levels upon 15 min for 13% (at p < 0.05) up to 19.11% upon 120 min (without statistical significance) in clinoptilolite pre-treated mice fed by addition of d-glucose. Due to lack of explicit mechanistic knowledge on zeolite clinoptilolite interactions or adsorption with sugars in vitro and in vivo, presented study provides novel insights into these aspects for researchers in the field. The presented data merit further investigations as the material clearly shows a potential in management of hyperglycemia, such as for example in obese people, people with diabetes and people with metabolic syndrome where it could help regulate blood glucose levels.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zeolitas Limite: Animals / Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Croácia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zeolitas Limite: Animals / Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Croácia