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Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation.
Huang, Junli; Ma, Zeli; Yang, Zichao; He, Zengzhu; Bao, Jingna; Peng, Xiaopeng; Liu, Yao; Chen, Ting; Cai, Shumin; Chen, Jianjun; Zeng, Zhenhua.
Afiliação
  • Huang J; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
  • Ma Z; Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Yang Z; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
  • He Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Bao J; Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Peng X; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Jiangxi Province Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering, School of Pharmacy, Gannan Medical University, Ganzhou, 314000, China.
  • Liu Y; Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
  • Chen T; Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: 252199453@qq.com.
  • Cai S; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: 13751845166@163.com.
  • Chen J; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: jchen21@smu.edu.cn.
  • Zeng Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: zhenhuazeng.2008@163.com.
Eur J Med Chem ; 259: 115664, 2023 Nov 05.
Article em En | MEDLINE | ID: mdl-37487306
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Quimera de Direcionamento de Proteólise Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Quimera de Direcionamento de Proteólise Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China