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Super-enhancers complexes zoom in transcription in cancer.
Wang, MengTing; Chen, QingYang; Wang, ShuJie; Xie, Han; Liu, Jun; Huang, RuiXiang; Xiang, YuFei; Jiang, YanYi; Tian, DaSheng; Bian, ErBao.
Afiliação
  • Wang M; Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.
  • Chen Q; Institute of Orthopaedics, Research Center for Translational Medicine, The Second Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230601, China.
  • Wang S; School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
  • Xie H; Department of Clinical MedicineThe Second School of Clinical Medical, Anhui Medical University, Hefei, China.
  • Liu J; Department of Clinical MedicineThe Second School of Clinical Medical, Anhui Medical University, Hefei, China.
  • Huang R; Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.
  • Xiang Y; Institute of Orthopaedics, Research Center for Translational Medicine, The Second Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230601, China.
  • Jiang Y; Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.
  • Tian D; Institute of Orthopaedics, Research Center for Translational Medicine, The Second Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230601, China.
  • Bian E; Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.
J Exp Clin Cancer Res ; 42(1): 183, 2023 Jul 28.
Article em En | MEDLINE | ID: mdl-37501079
Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote tumorigenesis and malignancy by altering protein-coding gene expression and noncoding regulatory element function. Therefore, they play central roles in the treatment of cancer. Here, we review the structural characteristics, organization, identification, and functions of SEs and the underlying molecular mechanism by which SEs drive oncogenic transcription in tumor cells. We then summarize abnormal SE complexes, SE-driven coding genes, and noncoding RNAs involved in tumor development. In summary, we believe that SEs show great potential as biomarkers and therapeutic targets.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elementos Facilitadores Genéticos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elementos Facilitadores Genéticos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido