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In Vivo Assessment of High-Strength and Corrosion-Controlled Magnesium-Based Bone Implants.
Ibrahim, Hamdy; Billings, Caroline; Abdalla, Moataz; Korra, Ahmed; Anderson, David Edger.
Afiliação
  • Ibrahim H; Department of Mechanical Engineering, University of Tennessee, Chattanooga, TN 37403, USA.
  • Billings C; College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
  • Abdalla M; Department of Mechanical Engineering, University of Tennessee, Chattanooga, TN 37403, USA.
  • Korra A; Department of Mechanical Engineering, University of Tennessee, Chattanooga, TN 37403, USA.
  • Anderson DE; College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Bioengineering (Basel) ; 10(7)2023 Jul 24.
Article em En | MEDLINE | ID: mdl-37508904
ABSTRACT
The biodegradable nature of magnesium in aqueous mediums makes it an attractive material for various biomedical applications when it is not recommended that the material stay permanently in the body. Some of the main challenges that hinder the use of magnesium for bone fracture repair are its limited mechanical strength and fast corrosion rates. To this end, we developed a novel Mg-Zn-Ca-Mn-based alloy and post-fabrication methods that can deliver high-strength and corrosion-controlled implant materials to address these challenges. This study is focused on assessing the in vitro corrosion and in vivo biocompatibility of the developed magnesium-based alloy and post-fabrication processes. The developed heat treatment process resulted in an increase in the microhardness from 71.9 ± 5.4 HV for the as-cast Mg alloy to as high as 98.1 ± 6.5 HV for the heat-treated Mg alloy, and the ceramic coating resulted in a significant reduction in the corrosion rate from 10.37 mm/yr for the uncoated alloy to 0.03 mm/yr after coating. The in vivo assessments showed positive levels of biocompatibility in terms of degradation rates and integration of the implants in a rabbit model. In the rabbit studies, the implants became integrated into the bone defect and showed minimal evidence of an immune response. The results of this study show that it is possible to produce biocompatible Mg-based implants with stronger and more corrosion-controlled properties based on the developed Mg-Zn-Ca-Mn-based alloy and post-fabrication methods.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Bioengineering (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Bioengineering (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos