The effects of stem cells and platelet-rich fibrin on colonic anastomosis: An experimental study.
Ann Ital Chir
; 93: 316-321, 2023.
Article
em En
| MEDLINE
| ID: mdl-37530065
ABSTRACT
AIM - Anastomotic leakage is among the most common complications following gastrointestinal surgery. MATERIAL AND METHODS - This study aimed to determine the effects of stem cells and platelet-rich fibrin (PRF) on anastomotic healing. The study included 60 rats that were randomly divided into 3 groups, each with 2 subgroups. The study included the control group (no treatment post anastomosis), the PRF group (PRF administered following anastomosis), and the PRF + stem cell group (PRF + stem cells administered following anastomosis). Anastomosis was performed at the descending colon in all groups. Anastomosis bursting pressure was determined, and histopathological and angiographic examination were performed on postoperative D 7. RESULTS - Intraabdominal adhesion was significantly more common in the control group. Anastomosis bursting pressure was significantly higher and angiogenesis was significantly more common in the PRF + stem cell group (P < 0.005). Based on histopathologic examination, vascular proliferation and inflammation were significantly more common in the PRF + stem cell group than in the control group (P < 0.005). CONCLUSION:
In cases of risky gastrointestinal system anastomosis, PRF + stem cells might reduce the incidence of anastomotic healing. KEY WORDS Anastomosis, Platelet-rich fibrin, Stem cell, Wound healing.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrina Rica em Plaquetas
Limite:
Animals
Idioma:
En
Revista:
Ann Ital Chir
Ano de publicação:
2023
Tipo de documento:
Article