Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and <i>in silico</i> studies.

Eissa, Ibrahim H; Yousef, Reda G; Elkady, Hazem; Elkaeed, Eslam B; Alsfouk, Aisha A; Husein, Dalal Z; Ibrahim, Ibrahim M; Elhendawy, Mostafa A; Godfrey, Murrell; Metwaly, Ahmed M

Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies.

Eissa, Ibrahim H; Yousef, Reda G; Elkady, Hazem; Elkaeed, Eslam B; Alsfouk, Aisha A; Husein, Dalal Z; Ibrahim, Ibrahim M; Elhendawy, Mostafa A; Godfrey, Murrell; Metwaly, Ahmed M.

Afiliação

Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo11884 Egypt Ibrahimeissa@azhar.edu.eg.
Yousef RG; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo11884 Egypt Ibrahimeissa@azhar.edu.eg.
Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo11884 Egypt Ibrahimeissa@azhar.edu.eg.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University Riyadh 13713 Saudi Arabia.
Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia.
Husein DZ; Chemistry Department, Faculty of Science, New Valley University El-Kharja 72511 Egypt.
Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University Cairo 12613 Egypt.
Elhendawy MA; Department of Chemistry and Biochemistry, University of Mississippi University MS 38677 USA.
Godfrey M; Department of Agriculture Chemistry, Faculty of Agriculture, Damietta University Damietta Egypt.
Metwaly AM; Department of Chemistry and Biochemistry, University of Mississippi University MS 38677 USA.

RSC Adv ; 13(33): 23285-23307, 2023 Jul 26.

Article em En | MEDLINE | ID: mdl-37538515

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: RSC Adv Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido

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