In-plane Extended Nano-coulter Counter (XnCC) for the Label-free Electrical Detection of Biological Particles.
Electroanalysis
; 34(12): 1961-1975, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-37539083
ABSTRACT
We report an in-plane extended nanopore Coulter counter (XnCC) chip fabricated in a thermoplastic via imprinting. The fabrication of the sensor utilized both photolithography and focused ion beam milling to make the microfluidic network and the in-plane pore sensor, respectively, in Si from which UV resin stamps were generated followed by thermal imprinting to produce the final device in the appropriate plastic (cyclic olefin polymer, COP). As an example of the utility of this in-plane extended nanopore sensor, we enumerated SARS-CoV-2 viral particles (VPs) affinity-selected from saliva and extracellular vesicles (EVs) affinity-selected from plasma samples secured from mouse models exposed to different ionizing radiation doses.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Electroanalysis
Ano de publicação:
2022
Tipo de documento:
Article