Safety Summary of Pediatric Inflammatory Bowel Disease Therapies.
Gastroenterol Clin North Am
; 52(3): 535-548, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37543398
ABSTRACT
Therapeutic options for the treatment of pediatric inflammatory bowel disease include aminosalicylates, enteral nutrition, corticosteroids, immunomodulators, biologics, and emerging small molecule agents. Infectious risk due to systemic immunosuppression should be mitigated by appropriate screening before therapy initiation. Rare but serious malignancies have been associated with thiopurine use alone and in combination with anti-tumor necrosis factor agents, often in the setting of a primary Epstein-Barr virus infection. Potential agent-specific adverse events such as cytopenias, hepatotoxicity, and nephrotoxicity warrant regular clinical and laboratory monitoring.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Infecções por Vírus Epstein-Barr
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Limite:
Child
/
Humans
Idioma:
En
Revista:
Gastroenterol Clin North Am
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article