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Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against Mycobacterium tuberculosis DNA gyrase.
Tantak, Mukund; Rayala, Ramanjaneyulu; Deng, Zifang; Bunnell, Ashley; Wang, Ting; Chaudhari, Prakash; Leng, Fenfei; Nefzi, Adel.
Afiliação
  • Tantak M; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
  • Rayala R; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
  • Deng Z; Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
  • Bunnell A; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
  • Wang T; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
  • Chaudhari P; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
  • Leng F; Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
  • Nefzi A; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA; Herbert Wertheim College of Medicine, FIU, 11200 SW 8th St, Miami, FL 33199, USA. Electronic address: anefzi@fiu.edu.
Bioorg Med Chem Lett ; 93: 129439, 2023 09 01.
Article em En | MEDLINE | ID: mdl-37557925
ABSTRACT
Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields. We report the design and the parallel synthesis of novel linear oligocyclic guanidine peptidomimetics from predesigned reduced polyamides. A screening of these compounds identified active Mycobacterium tuberculosis DNA gyrase inhibitors which do not inhibit human DNA topoisomerase IIα and topoisomerase I.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Peptidomiméticos / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Peptidomiméticos / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos