Modelling smart drug release with functionally graded materials.
Comput Biol Med
; 164: 107294, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37562324
ABSTRACT
Functionally graded materials (FGMs), possessing properties that vary smoothly from one region to another, have been receiving increasing attention in recent years, particularly in the aerospace, automotive and biomedical sectors. However, they have yet to reach their full potential. In this paper, we explore the potential of FGMs in the context of drug delivery, where the unique material characteristics offer the potential of fine-tuning drug-release for the desired application. Specifically, we develop a mathematical model of drug release from a thin film FGM, based upon a spatially-varying drug diffusivity. We demonstrate that, depending on the functional form of the diffusivity (related to the material properties) a wide range of drug release profiles may be obtained. Interestingly, the shape of these release profiles are not, in general, achievable from a homogeneous medium with a constant diffusivity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Modelos Teóricos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Comput Biol Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália