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Structure, function, and inhibition of catalytically asymmetric ABC transporters: Lessons from the PDR subfamily.
Banerjee, Atanu; Pata, Jorgaq; Chaptal, Vincent; Boumendjel, Ahcène; Falson, Pierre; Prasad, Rajendra.
Afiliação
  • Banerjee A; Amity Institute of Biotechnology and Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurugram, India. Electronic address: abanerjee1@ggn.amity.edu.
  • Pata J; Drug Resistance & Membrane Proteins group, CNRS-Lyon 1 University Laboratory 5086, IBCP, Lyon, France.
  • Chaptal V; Drug Resistance & Membrane Proteins group, CNRS-Lyon 1 University Laboratory 5086, IBCP, Lyon, France.
  • Boumendjel A; Univ. Grenoble Alpes, INSERM, LRB, Grenoble, France. Electronic address: Ahcene.Boumendjel@univ-grenoble-alpes.fr.
  • Falson P; Drug Resistance & Membrane Proteins group, CNRS-Lyon 1 University Laboratory 5086, IBCP, Lyon, France. Electronic address: pierre.falson@ibcp.fr.
  • Prasad R; Amity Institute of Biotechnology and Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurugram, India. Electronic address: rprasad@ggn.amity.edu.
Drug Resist Updat ; 71: 100992, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37567064
ATP-binding cassette (ABC) superfamily comprises a large group of ubiquitous transmembrane proteins that play a crucial role in transporting a diverse spectrum of substrates across cellular membranes. They participate in a wide array of physiological and pathological processes including nutrient uptake, antigen presentation, toxin elimination, and drug resistance in cancer and microbial cells. ABC transporters couple ATP binding and hydrolysis to undergo conformational changes allowing substrate translocation. Within this superfamily, a set of ABC transporters has lost the capacity to hydrolyze ATP at one of their nucleotide-binding sites (NBS), called the non-catalytic NBS, whose importance became evident with extensive biochemistry carried out on yeast pleiotropic drug resistance (PDR) transporters. Recent single-particle cryogenic electron microscopy (cryo-EM) advances have further catapulted our understanding of the architecture of these pumps. We provide here a comprehensive overview of the structural and functional aspects of catalytically asymmetric ABC pumps with an emphasis on the PDR subfamily. Furthermore, given the increasing evidence of efflux-mediated antifungal resistance in clinical settings, we also discuss potential grounds to explore PDR transporters as therapeutic targets.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Transportadores de Cassetes de Ligação de ATP Limite: Humans Idioma: En Revista: Drug Resist Updat Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Transportadores de Cassetes de Ligação de ATP Limite: Humans Idioma: En Revista: Drug Resist Updat Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido