Synthesis of Difluoromethylated Alkenes via Copper-Catalyzed Protodefluorination of ß-(Trifluoromethyl)styrenes.

Dong, Tao; Ye, Yibin; Wang, Yanhui; Cheung, Kelvin Pak Shing; Tsui, Gavin Chit

Dong, Tao; Ye, Yibin; Wang, Yanhui; Cheung, Kelvin Pak Shing; Tsui, Gavin Chit.

Afiliação

Dong T; Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Ye Y; Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Wang Y; Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Cheung KPS; Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Tsui GC; Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Chem Asian J ; 18(19): e202300655, 2023 Oct 04.

Article em En | MEDLINE | ID: mdl-37591794

ABSTRACT

ABSTRACT

Under typical copper-catalyzed hydroboration conditions, ß-(trifluoromethyl)styrenes demonstrate unusal reactivities by forming difluoromethylated alkenes via a net protodefluorination process. This is also distinct from trifluoromethyl alkenes with alkyl substituents where defluoroborylation products predominate.

Palavras-chave

copper catalysis; defluoroborylation; difluoromethyl alkenes; hydroboration; protodefluorination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Asian J Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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