Bioconcentration Assessment in Fish Based on In Vitro Intrinsic Clearance: Predictivity of an Empirical Model Compared to In Vitro-In Vivo Extrapolation Models.

Laue, Heike; Hostettler, Lu; Jenner, Karen J; Sanders, Gordon; Natsch, Andreas

Laue, Heike; Hostettler, Lu; Jenner, Karen J; Sanders, Gordon; Natsch, Andreas.

Afiliação

Laue H; Fragrances S&T, Givaudan Schweiz AG, Kemptthal 8310, Switzerland.
Hostettler L; Fragrances S&T, Givaudan Schweiz AG, Kemptthal 8310, Switzerland.
Jenner KJ; Regulatory Affairs & Product Safety, Fragrance & Beauty, Givaudan UK Ltd, Ashford, Kent, TN24 OLT, United Kingdom.
Sanders G; Regulatory Affairs & Product Safety, Fragrance & Beauty, Givaudan International SA,Vernier 1214, Switzerland.
Natsch A; Fragrances S&T, Givaudan Schweiz AG, Kemptthal 8310, Switzerland.

Environ Sci Technol ; 57(36): 13325-13335, 2023 09 12.

Article em En | MEDLINE | ID: mdl-37643004

Assuntos

Bioensaio; Peixes; Animais; Bioacumulação; Cinética; Incerteza

Palavras-chave

bioaccumulation; biotransformation; common carp; metabolism; new approach methodologies; rainbow trout; regression analysis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bioensaio / Peixes Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Environ Sci Technol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça

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