Low-density lipoprotein cholesterol, statin therapy, and cerebral microbleeds: The CIRCLE study.
Neuroimage Clin
; 39: 103502, 2023.
Article
em En
| MEDLINE
| ID: mdl-37643520
ABSTRACT
BACKGROUND:
Current evidence suggests a potential association between cerebral microbleeds (CMBs), low-density lipoprotein cholesterol (LDL-C) levels, and statin use, but the exact relationship remains unclear. This study aims to prospectively examine these relationships in a stroke-free population.METHODS:
From January 2010 to January 2020, we enrolled stroke-free individuals with at least one cerebral small vessel disease imaging marker from the CIRCLE study (ClinicalTrials.gov ID NCT03542734). Participants underwent baseline and 1-year follow-up susceptibility-weighted imaging (SWI), and baseline LDL-C testing. New CMBs were categorized as strictly lobar and deep CMBs based on location.RESULTS:
A total of 209 individuals were included. Baseline serum LDL-C levels were divided into quartiles Q1 (≤1.76 mmol/L), Q2 (1.77-2.36 mmol/L), Q3 (2.37-2.93 mmol/L), and Q4 (>2.93 mmol/L). The incidence of new deep CMBs was 30.0%, 11.1%, 10.9%, 8.2% in Q1, Q2, Q3, Q4, respectively. Multivariate logistic model revealed that only LDL-C in Q1 was associated with increased incidence of new deep CMBs (OR = 4.256; 95% CI 1.156-15.666; p = 0.029). In a subset of 169 participants without prior statin use, the use of atorvastatin was associated with reduced occurrence of new deep CMBs (OR = 0.181; 95% CI 0.035-0.928; p = 0.040), while it was not found with rosuvastatin (OR = 0.808; 95% CI 0.174-3.741; p = 0.785).CONCLUSIONS:
While lower LDL-C levels were associated with higher CMB development, statin therapy did not increase the risk of new CMBs. Atorvastatin even demonstrated a protective effect.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Acidente Vascular Cerebral
/
Doenças de Pequenos Vasos Cerebrais
Limite:
Humans
Idioma:
En
Revista:
Neuroimage Clin
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China