Deep screening of proximal and distal splicing-regulatory elements in a native sequence context.

Recinos, Yocelyn; Ustianenko, Dmytro; Yeh, Yow-Tyng; Wang, Xiaojian; Jacko, Martin; Yesantharao, Lekha V; Wu, Qiyang; Zhang, Chaolin

Recinos, Yocelyn; Ustianenko, Dmytro; Yeh, Yow-Tyng; Wang, Xiaojian; Jacko, Martin; Yesantharao, Lekha V; Wu, Qiyang; Zhang, Chaolin.

Afiliação

Recinos Y; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
Ustianenko D; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
Yeh YT; Present address: Flagship Pioneering, Cambridge, MA 02142, USA.
Wang X; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
Jacko M; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
Yesantharao LV; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
Wu Q; Present address: Aperture Therapeutics, Inc., San Carlos, CA 94070, USA.
Zhang C; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.

bioRxiv ; 2023 Aug 21.

Article em En | MEDLINE | ID: mdl-37662340

Palavras-chave

SMN2; alternative splicing; antisense oligonucleotides (ASO); dCas13d/guide RNA; high-throughput screen; splicing-regulatory elements (SREs)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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