Development of a Chimeric Protein BiPPB-mIFNÎ³-tTßRII for Improving the Anti-Fibrotic Activity in Vivo by Targeting Fibrotic Liver and Dual Inhibiting the TGF-ß1/Smad Signaling Pathway.

Dong, Yixin; Wang, Xiaohua; Xu, Liming; Li, Xin; Dai, Haibing; Mao, Xu; Chu, Yanhui; Yuan, Xiaohuan; Liu, Haifeng

Dong, Yixin; Wang, Xiaohua; Xu, Liming; Li, Xin; Dai, Haibing; Mao, Xu; Chu, Yanhui; Yuan, Xiaohuan; Liu, Haifeng.

Afiliação

Dong Y; Heilongjiang Province Key Laboratory for Anti-fibrosis Biotherapy, Mudanjiang Medical University, 157011, Mudanjiang, PR China.
Wang X; Laboratory of Pathogenic Microbiology and Immunology, Mudanjiang Medical University, 157011, Mudanjiang, PR China.
Xu L; Heilongjiang Province Key Laboratory for Anti-fibrosis Biotherapy, Mudanjiang Medical University, 157011, Mudanjiang, PR China.
Li X; Department of Pediatrics, Hongqi Hospital Affiliated to Mudanjiang Medical University, 157011, Mudanjiang, PR China.
Dai H; Department of Biology, Mudanjiang Medical University, 157011, Mudanjiang, PR China.
Mao X; Department of Pharmacology, Mudanjiang Medical University, 157011, Mudanjiang, PR China.
Chu Y; Heilongjiang Province Key Laboratory for Anti-fibrosis Biotherapy, Mudanjiang Medical University, 157011, Mudanjiang, PR China.
Yuan X; Heilongjiang Province Key Laboratory for Anti-fibrosis Biotherapy, Mudanjiang Medical University, 157011, Mudanjiang, PR China. yuanxiaohuan@mdjmu.edu.cn.
Liu H; Heilongjiang Province Key Laboratory for Anti-fibrosis Biotherapy, Mudanjiang Medical University, 157011, Mudanjiang, PR China. fenghailiu510@163.com.

Protein J ; 42(6): 753-765, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37690089

Palavras-chave

Interferon-gamma; Liver fibrosis; Platelet-derived growth factor ß receptor; TGF-ß receptor type II; Transforming growth factor ß1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Protein J Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Holanda

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