The preventive effect of prednisolone on the adrenal toxicity of cadmium.
J Appl Toxicol
; 6(5): 377-8, 1986 Oct.
Article
em En
| MEDLINE
| ID: mdl-3772015
ABSTRACT
The effects of a single dose of 3.3 mg/kg body weight i.p. or of a single dose of 0.2 mg/kg per os of cadmium and prednisolone on the adrenal weight and the thickness of the adrenal cortex were investigated in female mice. A significant increase was detected in the mean weight of the adrenals and the thickness of the adrenal cortex was significantly higher than the control value on days 1-3 following cadmium treatment. A dramatic decrease was observed in both adrenal weight and adrenal cortex thickness on day 4 following cadmium administration. No significant change occurred in the adrenals when prednisolone was given orally to mice following cadmium administration. This observation indicates a protective action of prednisolone on cadmium-induced adrenal toxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intoxicação por Cádmio
/
Prednisolona
/
Glândulas Suprarrenais
Limite:
Animals
Idioma:
En
Revista:
J Appl Toxicol
Ano de publicação:
1986
Tipo de documento:
Article