Biomaterials are the key to unlock spheroid function and therapeutic potential.
Biomater Biosyst
; 11: 100080, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37720486
ABSTRACT
Spheroids are three-dimensional cell aggregates that mimic fundamental aspects of the native tissue microenvironment better than single cells, making them a promising platform for the study of tissue development and therapeutics. Spheroids have been investigated for decades as models in cancer research, yet we have only just scratched the surface of their potential clinical utility in cell-based therapies. Like many cells, spheroids commonly exhibit a loss of key attributes upon implantation, motivating the need for strategies to regulate their function in situ. Biomaterials offer numerous opportunities to preserve spheroid function and guide spheroid behavior by tailoring the local microenvironment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Biomater Biosyst
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos