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Deamination-triggered exponential signal amplification for chemiluminescent detection of cytosine deaminase at the single-cell level.
Liu, Wen-Jing; Li, Hai-Juan; Zou, Xiaoran; Liu, Qian; Ma, Fei; Zhang, Chun-Yang.
Afiliação
  • Liu WJ; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China.
  • Li HJ; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. zhangcy@seu.edu.cn.
  • Zou X; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China.
  • Liu Q; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China.
  • Ma F; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. zhangcy@seu.edu.cn.
  • Zhang CY; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. zhangcy@seu.edu.cn.
Chem Commun (Camb) ; 59(79): 11807-11810, 2023 Oct 04.
Article em En | MEDLINE | ID: mdl-37721021
ABSTRACT
We construct a sensitive chemiluminescent biosensor for sensitive detection of cytosine deaminase APOBEC3A based on deamination-triggered exponential signal amplification. This biosensor displays good specificity and high sensitivity, and it can screen APOBEC3A inhibitors and measure endogenous APOBEC3A at the single-cell level, with prospective applications in disease diagnostics and therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Citosina Desaminase Tipo de estudo: Diagnostic_studies Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Citosina Desaminase Tipo de estudo: Diagnostic_studies Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China