CHB patients with rtA181T-mutated HBV infection are associated with higher risk hepatocellular carcinoma due to increases in mutation rates of tumour suppressor genes.

Ning, Qiqi; Yang, Tongwang; Guo, Xianghua; Huang, Yanxiang; Gao, Yuxue; Liu, Mengcheng; Yang, Pengxiang; Guan, Yuanyue; Liu, Ning; Wang, Yang; Chen, Dexi

Ning, Qiqi; Yang, Tongwang; Guo, Xianghua; Huang, Yanxiang; Gao, Yuxue; Liu, Mengcheng; Yang, Pengxiang; Guan, Yuanyue; Liu, Ning; Wang, Yang; Chen, Dexi.

Afiliação

Ning Q; Beijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing, China.
Yang T; Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, China.
Guo X; Academician Workstation, Changsha Medical University, Changsha, China.
Huang Y; Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, China.
Gao Y; Beijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing, China.
Liu M; Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, China.
Yang P; Clinical laboratory center, Beijing You An Hospital, Capital Medical University, Beijing, China.
Guan Y; Beijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing, China.
Liu N; Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, China.
Wang Y; Beijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing, China.
Chen D; Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, China.

J Viral Hepat ; 30(12): 951-958, 2023 12.

Article em En | MEDLINE | ID: mdl-37735836

Assuntos

Carcinoma Hepatocelular; Hepatite B Crônica; Neoplasias Hepáticas; Humanos; Vírus da Hepatite B/genética; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/tratamento farmacológico; Hepatite B Crônica/tratamento farmacológico; Antivirais/uso terapêutico; Taxa de Mutação; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/tratamento farmacológico; Mutação; Genes Supressores de Tumor; DNA Viral/genética; Antígenos de Superfície da Hepatite B/genética

Palavras-chave

HBsAg; ROS; hepatitis B virus; rtA181T mutation; rtA181V mutation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Hepatite B Crônica / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Viral Hepat Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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