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Performance of a [18F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies.
Coomans, Emma M; de Koning, Lotte A; Rikken, Roos M; Verfaillie, Sander C J; Visser, Denise; den Braber, Anouk; Tomassen, Jori; van de Beek, Marleen; Collij, Lyduine E; Lemstra, Afina W; Windhorst, Albert D; Barkhof, Frederik; Golla, Sandeep S V; Visser, Pieter Jelle; Scheltens, Philip; van der Flier, Wiesje M; Ossenkoppele, Rik; van Berckel, Bart N M; van de Giessen, Elsmarieke.
Afiliação
  • Coomans EM; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • de Koning LA; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Rikken RM; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Verfaillie SCJ; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Visser D; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • den Braber A; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Tomassen J; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • van de Beek M; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Collij LE; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Lemstra AW; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Windhorst AD; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Barkhof F; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Golla SSV; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Visser PJ; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Scheltens P; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • van der Flier WM; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • Ossenkoppele R; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • van Berckel BNM; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
  • van de Giessen E; From the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B.,
Neurology ; 101(19): e1850-e1862, 2023 11 07.
Article em En | MEDLINE | ID: mdl-37748892
BACKGROUND AND OBJECTIVES: Recently, the US Food and Drug Administration approved the tau-binding radiotracer [18F]flortaucipir and an accompanying visual read method to support the diagnostic process in cognitively impaired patients assessed for Alzheimer disease (AD). Studies evaluating this visual read method are limited. In this study, we evaluated the performance of the visual read method in participants along the AD continuum and dementia with Lewy bodies (DLB) by determining its reliability, accordance with semiquantitative analyses, and associations with clinically relevant variables. METHODS: We included participants who underwent tau-PET at Amsterdam University Medical Center. A subset underwent follow-up tau-PET. Two trained nuclear medicine physicians visually assessed all scans. Inter-reader agreement was calculated using Cohen κ. To examine the concordance of visual read tau positivity with semiquantification, we defined standardized uptake value ratio (SUVr) positivity using different threshold approaches. To evaluate the prognostic value of tau-PET visual read, we performed linear mixed models with longitudinal Mini-Mental State Examination (MMSE). RESULTS: We included 263 participants (mean age 68.5 years, 45.6% female), including 147 cognitively unimpaired (CU) participants, 97 amyloid-positive participants with mild cognitive impairment or AD dementia (AD), and 19 participants with DLB. The visual read inter-reader agreement was excellent (κ = 0.95, CI 0.91-0.99). None of the amyloid-negative CU participants (0/92 [0%]) and 1 amyloid-negative participant with DLB (1/12 [8.3%]) were tau-positive. Among amyloid-positive participants, 13 CU participants (13/52 [25.0%]), 85 with AD (85/97 [87.6%]), and 3 with DLB (3/7 [42.9%]) were tau-positive. Two-year follow-up visual read status was identical to baseline. Tau-PET visual read corresponded strongly to SUVr status, with up to 90.4% concordance. Visual read tau positivity was associated with a decline on the MMSE in CU participants (ß = -0.52, CI -0.74 to -0.30, p < 0.001) and participants with AD (ß = -0.30, CI -0.58 to -0.02, p = 0.04). DISCUSSION: The excellent inter-reader agreement, strong correspondence with SUVr, and longitudinal stability indicate that the visual read method is reliable and robust, supporting clinical application. Furthermore, visual read tau positivity was associated with prospective cognitive decline, highlighting its additional prognostic potential. Future studies in unselected cohorts are needed for a better generalizability to the clinical population. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that [18F]flortaucipir visual read accurately distinguishes patients with low tau-tracer binding from those with high tau-tracer binding and is associated with amyloid positivity and cognitive decline.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Neurology Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Neurology Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos