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Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation.
Nies, Anne T; König, Jörg; Leuthold, Patrick; Damme, Katja; Winter, Stefan; Haag, Mathias; Masuda, Satohiro; Kruck, Stephan; Daniel, Hannelore; Spanier, Britta; Fromm, Martin F; Bedke, Jens; Inui, Ken-Ichi; Schwab, Matthias; Schaeffeler, Elke.
Afiliação
  • Nies AT; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Germany.
  • König J; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Leuthold P; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.
  • Damme K; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.
  • Winter S; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.
  • Haag M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.
  • Masuda S; Department of Clinical Pharmacology & Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan.
  • Kruck S; Department of Urology, University Hospital Tuebingen, Germany.
  • Daniel H; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
  • Spanier B; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
  • Fromm MF; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Bedke J; Department of Urology, University Hospital Tuebingen, Germany.
  • Inui KI; Kyoto Pharmaceutical University, Kyoto, Japan.
  • Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Germany; Departments of Clinical Pharmacology, Pharmacy
  • Schaeffeler E; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Germany.
Pharmacol Res ; 196: 106941, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37775020
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Proteínas Carreadoras de Solutos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Proteínas Carreadoras de Solutos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Holanda