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Neurotrophic phenolic glycosides from the roots of Armoracia rusticana.
Lee, Tae Hyun; Yoon, Da Hye; Park, Kyoung Jin; Hong, Seong-Min; Kim, Minji; Kim, Sun Yeou; Kim, Chung Sub; Lee, Kang Ro.
Afiliação
  • Lee TH; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
  • Yoon DH; Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea.
  • Park KJ; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
  • Hong SM; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea.
  • Kim M; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
  • Kim SY; Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea.
  • Kim CS; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: chungsub.kim@skku.edu.
  • Lee KR; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: krlee@skku.edu.
Phytochemistry ; 216: 113886, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37806466
ABSTRACT
Armoracia rusticana P. G. Gaertner. belongs to the Brassicaceae family and has aroused scientific interest for its anti-inflammatory and anticancer activities. In a continuing investigation to discover bioactive constituents from A. rusticana, we isolated 19 phenolic glycosides including three undescribed flavonol glycosides and one undescribed neolignan glycoside from MeOH extract of this plant. Their structures were elucidated based on NMR spectroscopic analysis (1H, 13C, 1H-1H COSY, HSQC, and HMBC), HRESIMS, and chemical methods. The determination of their absolute configuration was accomplished by ECD and LC-MS analysis. All the compounds were assessed for their potential neurotrophic activity through induction of nerve growth factor in C6 glioma cell lines and for their anti-neuroinflammatory activity based on the measurement of inhibition levels of nitric oxide production and pro-inflammatory cytokines (i.e., IL-1ß, IL-6, and TNF-α) in lipopolysaccharide-activated microglia BV-2 cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Armoracia / Glicosídeos Idioma: En Revista: Phytochemistry Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Armoracia / Glicosídeos Idioma: En Revista: Phytochemistry Ano de publicação: 2023 Tipo de documento: Article