Post COVID sequelae among COVID-19 survivors: insights from the Indian National Clinical Registry for COVID-19.
BMJ Glob Health
; 8(10)2023 10.
Article
em En
| MEDLINE
| ID: mdl-37816536
ABSTRACT
INTRODUCTION:
The effects of COVID-19 infection persist beyond the active phase. Comprehensive description and analysis of the post COVID sequelae in various population groups are critical to minimise the long-term morbidity and mortality associated with COVID-19. This analysis was conducted with an objective to estimate the frequency of post COVID sequelae and subsequently, design a framework for holistic management of post COVID morbidities.METHODS:
Follow-up data collected as part of a registry-based observational study in 31 hospitals across India since September 2020-October 2022 were used for analysis. All consenting hospitalised patients with COVID-19 are telephonically followed up for up to 1 year post-discharge, using a prestructured form focused on symptom reporting.RESULTS:
Dyspnoea, fatigue and mental health issues were reported among 18.6%, 10.5% and 9.3% of the 8042 participants at first follow-up of 30-60 days post-discharge, respectively, which reduced to 11.9%, 6.6% and 9%, respectively, at 1-year follow-up in 2192 participants. Patients who died within 90 days post-discharge were significantly older (adjusted OR (aOR) 1.02, 95% CI 1.01, 1.03), with at least one comorbidity (aOR 1.76, 95% CI 1.31, 2.35), and a higher proportion had required intensive care unit admission during the initial hospitalisation due to COVID-19 (aOR 1.49, 95% CI 1.08, 2.06) and were discharged at WHO ordinal scale 6-7 (aOR 49.13 95% CI 25.43, 94.92). Anti-SARS-CoV-2 vaccination (at least one dose) was protective against such post-discharge mortality (aOR 0.19, 95% CI 0.01, 0.03).CONCLUSION:
Hospitalised patients with COVID-19 experience a variety of long-term sequelae after discharge from hospitals which persists although in reduced proportions until 12 months post-discharge. Developing a holistic management framework with engagement of care outreach workers as well as teleconsultation is a way forward in effective management of post COVID morbidities as well as reducing mortality.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
COVID-19
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
BMJ Glob Health
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Índia