Ligand-Enabled Double γ-C(sp3 )-H Functionalization of Aliphatic Acids: One-Step Synthesis of γ-Arylated γ-Lactones.
Angew Chem Int Ed Engl
; 62(49): e202312331, 2023 Dec 04.
Article
em En
| MEDLINE
| ID: mdl-37851865
ABSTRACT
γ-methylene C(sp3 )-H functionalization of linear free carboxylic acids remains a significant challenge. Here in we report a Pd(II)-catalyzed tandem γ-arylation and γ-lactonization of aliphatic acids enabled by a L,X-type CarboxPyridone ligand. A wide range of γ-arylated γ-lactones are synthesized in a single step from aliphatic acids in moderate to good yield. Arylated lactones can readily be converted into disubstituted tetrahydrofurans, a prominent scaffold amongst bioactive molecules.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos