Development of hyaluronic acid-silica composites via in situ precipitation for improved penetration efficiency in fast-dissolving microneedle systems.

Tay, Jie Hao; Lim, Yu Han; Zheng, Mengjia; Zhao, Yakai; Tan, Wen See; Xu, Chenjie; Ramamurty, Upadrasta; Song, Juha

Tay, Jie Hao; Lim, Yu Han; Zheng, Mengjia; Zhao, Yakai; Tan, Wen See; Xu, Chenjie; Ramamurty, Upadrasta; Song, Juha.

Afiliação

Tay JH; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 639798, Singapore.
Lim YH; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 639798, Singapore.
Zheng M; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China.
Zhao Y; Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 138634, Singapore.
Tan WS; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 639798, Singapore; Singapore Centre for 3D Printing, Nanyang Technological University, Singapore, 639798, Singapore.
Xu C; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China.
Ramamurty U; Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 138634, Singapore; Singapore Centre for 3D Printing, Nanyang Technological University, Singapore, 639798, Singapore; School of Mechanical and Aerospace Engineering, Nanyang Technological University, 639798,
Song J; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 639798, Singapore; Singapore Centre for 3D Printing, Nanyang Technological University, Singapore, 639798, Singapore. Electronic address: songjuha@ntu.edu.sg.

Acta Biomater ; 172: 175-187, 2023 12.

Article em En | MEDLINE | ID: mdl-37865280

Assuntos

Ácido Hialurônico; Pele; Humanos; Ácido Hialurônico/química; Administração Cutânea; Pele/metabolismo; Sistemas de Liberação de Medicamentos/métodos; Polímeros/química; Agulhas

Palavras-chave

Drug delivery; Hyaluronic acid-silica nanocomposite; In situ precipitation; Mechanical enhancement; Penetration efficiency; fast-dissolving microneedle system (DMS)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Ácido Hialurônico Limite: Humans Idioma: En Revista: Acta Biomater Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Singapura

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