Cytotoxic xanthones from Garcinia pedunculata fruits.

Zou, Deli; Liu, Fangshen; Liu, Lei; Xu, Huarong; Li, Dahong; Hua, Huiming

Zou, Deli; Liu, Fangshen; Liu, Lei; Xu, Huarong; Li, Dahong; Hua, Huiming.

Afiliação

Zou D; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Liu F; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Liu L; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Xu H; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: xuh@syphu.edu.cn.
Li D; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: lidahong0203@163.com.
Hua H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: huimhua@163.com.

Phytochemistry ; 217: 113898, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37875167

ABSTRACT

ABSTRACT

Eight previously undescribed and seven known xanthones were isolated from the fruits of Garcinia pedunculata Roxb. The structures were identified by a variety of spectroscopic methods as well as by comparison with the literature. The isolates showed appreciable cytotoxicity against three human tumor cell lines (HepG2, A549, and MCF-7). Pedunculaxanthone G exhibited inhibitory activities with IC50 values of 12.41, 16.51, and 15.45 µM against the cancer cell lines and induced cell apoptosis in HepG2 cells.

Assuntos

Antineoplásicos Fitogênicos; Antineoplásicos; Garcinia; Thoracica; Xantonas; Animais; Humanos; Garcinia/química; Xantonas/farmacologia; Xantonas/química; Frutas; Antineoplásicos Fitogênicos/farmacologia; Antineoplásicos Fitogênicos/química; Linhagem Celular Tumoral; Estrutura Molecular

Palavras-chave

Clusiaceae xanthones; Cytotoxicity; Garcinia pedunculata roxb

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Thoracica / Garcinia / Xantonas / Antineoplásicos / Antineoplásicos Fitogênicos Limite: Animals / Humans Idioma: En Revista: Phytochemistry Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido

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