Site-Specific Structural Changes in Long-Term-Stressed Monoclonal Antibody Revealed with DEPC Covalent-Labeling and Quantitative Mass Spectrometry.

Gaikwad, Manasi; Richter, Florian; Götz, Rabea; Dörrbaum, Aline; Schumacher, Lena; Tonillo, Jason; Frech, Christian; Kellner, Roland; Hopf, Carsten

Gaikwad, Manasi; Richter, Florian; Götz, Rabea; Dörrbaum, Aline; Schumacher, Lena; Tonillo, Jason; Frech, Christian; Kellner, Roland; Hopf, Carsten.

Afiliação

Gaikwad M; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.
Richter F; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.
Götz R; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.
Dörrbaum A; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.
Schumacher L; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.
Tonillo J; Merck Healthcare KGaA, ADCs & Targeted NBE Therapeutics, Frankfurter Str. 250, 64293 Darmstadt, Germany.
Frech C; Faculty of Biotechnology, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.
Kellner R; Merck Healthcare KGaA, ADCs & Targeted NBE Therapeutics, Frankfurter Str. 250, 64293 Darmstadt, Germany.
Hopf C; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.

Pharmaceuticals (Basel) ; 16(10)2023 Oct 05.

Article em En | MEDLINE | ID: mdl-37895889

Palavras-chave

diethyl pyrocarbonate labeling; heat stress; long-term storage; monoclonal antibody; site-specific labeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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