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Muscle-targeted nanoparticles strengthen the effects of small-molecule inhibitors in ameliorating sarcopenia.
Wang, Jinyu; He, Yikang; Wang, Baoyue; Yin, Ruian; Chen, Biao; Wang, Hongxing.
Afiliação
  • Wang J; Department of Rehabilitation, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China.
  • He Y; Department of Rehabilitation, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China.
  • Wang B; Lianshui People's Hospital of Kangda College Affiliated to Nanjing Medical University, Huaian, Jiangsu, PR China.
  • Yin R; Department of Rehabilitation, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China.
  • Chen B; Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, PR China.
  • Wang H; Department of Rehabilitation, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China.
Nanomedicine (Lond) ; 18(23): 1635-1649, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37909281
ABSTRACT

Background:

Sarcopenia is an aging-related degeneration of muscle mass and strength. Small-molecule inhibitor SW033291 has been shown to attenuate muscle atrophy. Targeted nanodrug-delivery systems can improve the efficacy of small-molecule inhibitors.

Methods:

The skeletal muscle cell-targeted nanoparticle was called AP@SW033291, which consisted of SW033291, modular peptide ASSLNIAGGRRRRRG and PEG-DSPE. Nanoparticles were featured with particle size, fluorescence emission spectra and targeting ability. We also investigated their effects on muscle mass and function.

Results:

The size of AP@SW033291 was 125.7 nm and it demonstrated targeting effects on skeletal muscle; thus, it could improve muscle mass and muscle function.

Conclusion:

Nanoparticle AP@SW033291 could become a potential strategy to strengthen the treatment effects of small-molecule inhibitors in sarcopenia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Sarcopenia Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Sarcopenia Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2023 Tipo de documento: Article