Use of lacosamide for focal epilepsy in a child with kidney failure undergoing peritoneal dialysis.
Brain Dev
; 46(2): 114-117, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-37914622
ABSTRACT
BACKGROUND:
Lacosamide (LCM) has become commonly used for focal onset seizures due to its high tolerability and low drug interactions. Unlike patients on hemodialysis (HD), pharmacokinetic data and dosing recommendations for patients undergoing peritoneal dialysis (PD) are scant. CASE REPORT A 2-year-old girl with end-stage kidney disease undergoing PD suffered prolonged focal onset seizures. The patient had congenital anomalies of the kidney and urinary tract associated with branchio-oto-renal syndrome due to an EYA1 gene mutation. She also had neurological sequelae from post-resuscitation encephalopathy at the age of one month. Antiseizure medication with few drug interactions, less impact on the neurodevelopmental state and possibility of intravenous administration was preferred. LCM met those criteria and was carefully administered. Although the patient had recurrent prolonged seizures during the titration periods, LCM could be continued without any apparent side effects. The blood levels of LCM increased linearly to the optimal level. We confirmed excretion of LCM in the PD fluid. Kidney transplantation was done three months after and her seizures were well controlled.CONCLUSIONS:
LCM might be a promising option for patients undergoing PD. Due to the lower removal efficacy in PD compared with in HD, close attention should be paid to possible drug excess.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diálise Peritoneal
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Epilepsias Parciais
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Epilepsia Generalizada
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Insuficiência Renal
Limite:
Child
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Child, preschool
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Female
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Humans
Idioma:
En
Revista:
Brain Dev
Ano de publicação:
2024
Tipo de documento:
Article