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No evidence for systemic low-grade inflammation in adult patients with early-treated phenylketonuria: The INGRAPH study.
Giret, Chloé; Dos Santos, Yann; Blasco, Hélène; Paget, Christophe; Gonzalez, Loïc; Tressel, Nathalie; Dieu, Maeva; Bigot, Adrien; Gissot, Valérie; Audemard-Verger, Alexandra; Maillot, François.
Afiliação
  • Giret C; Service de médecine interne CHRU de Tours Tours France.
  • Dos Santos Y; Université de Tours Tours France.
  • Blasco H; Université de Tours Tours France.
  • Paget C; UMR INSERM, "iBrain" 1253 Tours France.
  • Gonzalez L; Université de Tours Tours France.
  • Tressel N; UMR INSERM, "iBrain" 1253 Tours France.
  • Dieu M; Laboratoire de biochimie, CHRU de Tours Tours France.
  • Bigot A; Centre de référence des maladies héréditaires du métabolisme Tours France.
  • Gissot V; Université de Tours Tours France.
  • Audemard-Verger A; Centre d'étude des Pathologies Respiratoires (CEPR) UMR INSERM 1100 Tours France.
  • Maillot F; Université de Tours Tours France.
JIMD Rep ; 64(6): 446-452, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37927482
The question of an increased cardiovascular risk has been recently raised in adults with phenylketonuria (PKU). As low-grade systemic inflammation increases cardiovascular risk, the INGRAPH study aimed to evaluate low-grade inflammation in adult PKU patients compared to healthy controls and to determine the potential influence of Phe-controlled diet on inflammation. Twenty early-treated adult PKU patients, including a subgroup of 15 classical PKU patients, and 20 healthy volunteers were included. PKU patients and healthy subjects were matched on age, sex and body mass index class. Plasma concentrations of CRP, IFNg, IL1a, IL1b, IL2, IL6, IL10, and TNFα were measured in PKU patients and compared to controls. Plasma CRP was not different in the PKU group as compared to controls. No significant differences were observed between the two groups concerning plasma cytokines concentrations. Plasma CRP and cytokine profile were not different between "on diet" and "off diet" PKU patients. All these results were similar considering only the classical PKU subgroup. No differences were shown in plasma CRP and pro-inflammatory cytokines between adult PKU patients and healthy controls. Further studies are needed, including more patients and extensive characterization of systemic low-grade inflammation, as cardiovascular risk appears to be a new concern in adult PKU population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JIMD Rep Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JIMD Rep Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos