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Spleen stiffness determined by spleen-dedicated device accurately predicted esophageal varices in cirrhosis patients.
Liu, Jiqing; Xu, Hangfei; Liu, Weiyuan; Zu, Hongmei; Ding, Huiguo; Meng, Fankun; Zhang, Jing.
Afiliação
  • Liu J; Beijing Youan Hospital, Capital Medical University, Beijing, China.
  • Xu H; The Fourth People's Hospital of Qinghai Province, Xining, Qinghai, China.
  • Liu W; Beijing Youan Hospital, Capital Medical University, Beijing, China.
  • Zu H; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
  • Ding H; Beijing Youan Hospital, Capital Medical University, Beijing, China.
  • Meng F; The Fourth People's Hospital of Qinghai Province, Xining, Qinghai, China.
  • Zhang J; Beijing Youan Hospital, Capital Medical University, Beijing, China.
Ther Adv Chronic Dis ; 14: 20406223231206223, 2023.
Article em En | MEDLINE | ID: mdl-37928628
Background: The advantages of spleen stiffness in prediction of high-risk varices (HRV) in cirrhosis patients have been confirmed. Recently, a new device utilizing a 100 Hz probe dedicated to spleen stiffness measurement (SSM) was developed. Objectives: To validate the clinical applicability of SSM@100 Hz in predicting HRV by comparing it with other non-invasive tests (NITs). Design: A prospective cohort study. Methods: A total of 171 cirrhosis patients who underwent esophagogastroduodenoscopy (EGD) examination were included in this study. SSM using a 100 Hz probe and liver stiffness measurement using a 50 Hz probe were performed. Additionally, 22 healthy controls underwent spleen stiffness evaluation using the 100 Hz probe. Results: The failure rates of spleen stiffness examination in patients with cirrhosis and in healthy controls were 2.9% and 4.5%, respectively. The means of SSM values were 56.4 ± 21.6 and 13.8 ± 6.7 kPa in cirrhosis and controls. SSM increased proportionally with the severity of esophageal varices. The area under receiver operating characteristic (ROC) for spleen stiffness in predicting HRV was 0.881 (95% confidence interval 0.829-0.934), with a cutoff value of 43.4 kPa. The accuracy, false negative rate and EGD spare rate were 86.5%, 2.5% and 24.3%, respectively. For HRV prediction, SSM was comparable to expanded Baveno VI and VII and superior to other NITs. As to viral versus non-viral cirrhosis and compensated versus decompensated cirrhosis, the cut-off and performance of SSM were different. Conclusion: SSM@100 Hz demonstrates high accuracy in predicting HRV with a low missed HRV rate. Our findings suggest that SSM@100 Hz can be used independently due to its simplicity and effectiveness. However, further studies are needed to determine appropriate cutoff values based on the cause of cirrhosis and liver function. Trail Registration: ChiCTR2300070270.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Ther Adv Chronic Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Ther Adv Chronic Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos