Effects of short-term air pollution exposure on symptoms development in the course of idiopathic pulmonary fibrosis.
Expert Rev Respir Med
; 17(11): 1069-1078, 2023.
Article
em En
| MEDLINE
| ID: mdl-37937867
ABSTRACT
BACKGROUND:
Lately a potential detrimental effect of air pollution to idiopathic pulmonary fibrosis emerged. We aimed to assess the effects of short-term air pollution exposure to the clinical course of IPF. RESEARCH DESIGN ANDMETHODS:
IPF patients were followed intensively for four nonconsecutive study periods between 13 July 2020 and 5 September 2021. Short-term exposure to O3, NO2 and PM10 concentrations was estimated using spatio-temporal land use regression models. Associations among symptoms, lung function, oxygen saturation, and short-term personal air pollutant exposure were assessed through multiple mixed effects logistic regression models.RESULTS:
Data for up to 24 IPF patients (mean age 72.2 ± 7.6 years) were analyzed. We detected positive significant associations between cough and a 10 µg/m3 increase in same day mean level of NO2 (OR = 1.59, 95%CI 1.00-2.53), PM10 (OR = 2.42, 95%CI 1.54-3.79), and O3 (OR = 1.63, 95%CI 1.14-2.32). A 10 µg/m3 increase in same day mean level of NO2 was also associated with the risk of appearance of wheezing (OR = 3.01, 95%CI 1.00-9.04), while exposure to O3 was associated with common cold (OR = 6.30, 95%CI 3.59-11.07). No significant associations were detected between short-term exposure to air pollutants and forced vital capacity or saturation of oxygen.CONCLUSIONS:
Short-term exposure to increased concentrations of air pollutants is an independent risk factor for IPF symptoms' aggravation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ozônio
/
Poluentes Atmosféricos
/
Poluição do Ar
/
Fibrose Pulmonar Idiopática
Limite:
Aged
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Humans
/
Middle aged
Idioma:
En
Revista:
Expert Rev Respir Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Grécia
País de publicação:
ENGLAND
/
ESCOCIA
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GB
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GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
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UK
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UNITED KINGDOM