Von Willebrand factor promotes radiation-induced intestinal injury (RIII) development and its cleavage enzyme rhADAMTS13 protects against RIII by reducing inflammation and oxidative stress.

Xu, Jie; He, Jun; Zhou, Ya-Li; Weng, Zhen; Li, Ming; Wang, Zhen-Xin; He, Yang

Xu, Jie; He, Jun; Zhou, Ya-Li; Weng, Zhen; Li, Ming; Wang, Zhen-Xin; He, Yang.

Afiliação

Xu J; MOE Engineering Center of Hematological Disease, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, China; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, 215006, China.
He J; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Zhou YL; MOE Engineering Center of Hematological Disease, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, China; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, 215006, China.
Weng Z; MOE Engineering Center of Hematological Disease, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, China; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, 215006, China.
Li M; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, Ch
Wang ZX; Department of Medical Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address: zhenxw316@163.com.
He Y; MOE Engineering Center of Hematological Disease, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, China; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, 215006, China. Electronic address: heyang

Free Radic Biol Med ; 210: 1-12, 2024 01.

Article em En | MEDLINE | ID: mdl-37956910

Assuntos

Neoplasias do Colo do Útero; Fator de von Willebrand; Feminino; Humanos; Camundongos; Animais; Fator de von Willebrand/genética; Fator de von Willebrand/química; Fator de von Willebrand/metabolismo; Camundongos Endogâmicos C57BL; Inflamação/prevenção & controle; Estresse Oxidativo

Palavras-chave

Inflammation; Oxidative stress; Radiation-induced intestinal injury; rhADAMTS13; vWF/ADAMTS13 axis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de von Willebrand / Neoplasias do Colo do Útero Limite: Animals / Female / Humans Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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