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High ApoB/ApoA-I Ratio Predicts Post-Stroke Cognitive Impairment in Acute Ischemic Stroke Patients with Large Artery Atherosclerosis.
Lee, Minwoo; Lim, Jae-Sung; Kim, Yerim; Park, Soo Hyun; Lee, Sang-Hwa; Kim, Chulho; Lee, Byung-Chul; Yu, Kyung-Ho; Lee, Jae-Jun; Oh, Mi Sun.
Afiliação
  • Lee M; Department of Neurology, Hallym University Sacred Heart Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
  • Lim JS; Institute of New Frontier Research Team, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
  • Kim Y; Department of Neurology, Asan Medical Center, Ulsan University College of Medicine, Seoul 05505, Republic of Korea.
  • Park SH; Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 24252, Republic of Korea.
  • Lee SH; Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 24252, Republic of Korea.
  • Kim C; Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
  • Lee BC; Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
  • Yu KH; Department of Neurology, Hallym University Sacred Heart Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
  • Lee JJ; Department of Neurology, Hallym University Sacred Heart Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
  • Oh MS; Institute of New Frontier Research Team, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Nutrients ; 15(21)2023 Nov 04.
Article em En | MEDLINE | ID: mdl-37960323
BACKGROUND: We aimed to investigate the association between the ApoB/ApoA-I ratio and post-stroke cognitive impairment (PSCI) in patients with acute stroke of large artery atherosclerosis etiology. METHODS: Prospective stroke registry data were used to consecutively enroll patients with acute ischemic stroke due to large artery atherosclerosis. Cognitive function assessments were conducted 3 to 6 months after stroke. PSCI was defined as a z-score of less than -2 standard deviations from age, sex, and education-adjusted means in at least one cognitive domain. The ApoB/ApoA-I ratio was calculated, and patients were categorized into five groups according to quintiles of the ratio. Logistic regression analyses were performed to assess the association between quintiles of the ApoB/ApoA-I ratio and PSCI. RESULTS: A total of 263 patients were included, with a mean age of 65.9 ± 11.6 years. The median NIHSS score and ApoB/ApoA-I ratio upon admission were 2 (IQR, 1-5) and 0.81 (IQR, 0.76-0.88), respectively. PSCI was observed in 91 (34.6%) patients. The highest quintile (Q5) of the ApoB/ApoA-I ratio was a significant predictor of PSCI compared to the lowest quintile (Q1) (adjusted OR, 3.16; 95% CI, 1.19-8.41; p-value = 0.021) after adjusting for relevant confounders. Patients in the Q5 group exhibited significantly worse performance in the frontal domain. CONCLUSIONS: The ApoB/ApoA-I ratio in the acute stage of stroke independently predicted the development of PSCI at 3-6 months after stroke due to large artery atherosclerosis. Further, a high ApoB/ApoA-I ratio was specifically associated with frontal domain dysfunction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Aterosclerose / Disfunção Cognitiva / AVC Isquêmico Limite: Aged / Humans / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2023 Tipo de documento: Article País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Aterosclerose / Disfunção Cognitiva / AVC Isquêmico Limite: Aged / Humans / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2023 Tipo de documento: Article País de publicação: Suíça