Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4<sup>+</sup> T cells.

Sambaturu, Narmada; Fray, Emily J; Wu, Fengting; Zitzmann, Carolin; Simonetti, Francesco R; Barouch, Dan H; Siliciano, Janet D; Siliciano, Robert F; Ribeiro, Ruy M; Perelson, Alan S; Molina-París, Carmen; Leitner, Thomas

Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4⁺ T cells.

Sambaturu, Narmada; Fray, Emily J; Wu, Fengting; Zitzmann, Carolin; Simonetti, Francesco R; Barouch, Dan H; Siliciano, Janet D; Siliciano, Robert F; Ribeiro, Ruy M; Perelson, Alan S; Molina-París, Carmen; Leitner, Thomas.

Afiliação

Sambaturu N; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.
Fray EJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Wu F; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Zitzmann C; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.
Simonetti FR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Siliciano JD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ribeiro RM; Howard Hughes Medical Institute, Baltimore, MD 21205, USA.
Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.
Molina-París C; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.
Leitner T; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.

bioRxiv ; 2023 Nov 03.

Article em En | MEDLINE | ID: mdl-37961482

Palavras-chave

HIV; SIV; antiviral treatment; genetic divergence; latency

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article