Deficiency of aldehyde dehydrogenase 2 aggravates ethanol-induced cytotoxicity in N2a cells via CaMKII/Drp1-mediated mitophagy.

Yan, Tingting; Chen, Jiyang; Wang, Yalin; Wang, Yinuo; Zhang, Yuanqingzhi; Zhao, Yan

Yan, Tingting; Chen, Jiyang; Wang, Yalin; Wang, Yinuo; Zhang, Yuanqingzhi; Zhao, Yan.

Afiliação

Yan T; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, Shandong, China.
Chen J; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, Shandong, China.
Wang Y; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, Shandong, China.
Wang Y; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, Shandong, China.
Zhang Y; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, Shandong, China.
Zhao Y; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, Shandong, China. Electronic address: zhaoyan@hitwh.edu.cn.

Food Chem Toxicol ; 182: 114129, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37967785

Assuntos

Alcoolismo; Etanol; Humanos; Etanol/toxicidade; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Alcoolismo/complicações; Mitofagia; Dinaminas/genética; Dinaminas/metabolismo; Aldeído Desidrogenase; Aldeído-Desidrogenase Mitocondrial/genética

Palavras-chave

ALDH2; CaMKII; Drp1; Ethanol; Mitochondrial dysfunction; Mitophagy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Etanol / Alcoolismo Limite: Humans Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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