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Cumulative detection of anal high-grade squamous intraepithelial lesions over two-year follow-up in men who have sex with men living with HIV in France.
Combes, Jean-Damien; Didelot, Jean-Michel; Radenne, Sylvie; Zaegel-Faucher, Olivia; Lesage, Anne-Carole; Siproudhis, Laurent; Piroth, Lionel; Marchand, Lucie; Heard, Isabelle; Hoyeau, Nadia; Henno, Sébastien; Darragh, Teresa M; Alberts, Catharina J; Clifford, Gary M; Etienney, Isabelle.
Afiliação
  • Combes JD; International Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention, and Infections Branch, Lyon, France.
  • Didelot JM; Service d'Hépatogastroentérologie, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
  • Radenne S; Service d'Hépatologie, Hôpital de la Croix Rousse, Unité INSERM 1052, CHU Lyon, Lyon, France.
  • Zaegel-Faucher O; Service d'Immuno-Hématologie Clinique, Université Aix Marseille, APHM Sainte-Marguerite, Marseille, France.
  • Lesage AC; INSERM U912 (Sciences économiques et sociales de la santé et traitement de l'information médicale - SESSTIM), Marseille, France.
  • Siproudhis L; Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France.
  • Piroth L; Department of Gastroenterology, University Hospital of Rennes, Pontchaillou, Rennes, France.
  • Marchand L; INSERM U1241, University of Rennes 1, Rennes, France.
  • Heard I; INPHY CIC 1414 University Hospital of Rennes, Pontchaillou, Rennes, France.
  • Hoyeau N; Département d'Infectiologie, Centre Hospitalier Universitaire (CHU) de Dijon, Dijon, France.
  • Henno S; Institut National de la Sante et de la Recherche Medicale (INSERM) Centre d'Investigation Clinique (CIC) 1432, Université de Bourgogne, Dijon, France.
  • Darragh TM; ANRS MIE, Paris, France.
  • Alberts CJ; Centre National de Référence des HPV, Institut Pasteur, Paris, France.
  • Clifford GM; Hôpital Tenon, AP-HP, Paris, France.
  • Etienney I; Service d'Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, Groupe Hospitalier Hôpitaux Universitaires Est Parisien (GH HUEP), AP-HP, Paris, France.
J Infect Dis ; 2023 Nov 16.
Article em En | MEDLINE | ID: mdl-37970975
ABSTRACT
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSIL) in men who have sex with men living with HIV who underwent three visits over two years, with cytology and high-resolution anoscopy (HRA), within the ANRS-EP57-APACHES study. Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3.6-18.9), and p16/Ki67 (aOR 4.6; 95%CI 2.3-9.1). Repeat annual cytology and HRA improved HSIL detection but did not fully compensate between-center heterogeneity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: França